WNT3 antibody (AA 155-184)

Catalog No. ABIN3029628

Product Details anti-WNT3 Antibody

Target: WNT3 (Wingless-Type MMTV Integration Site Family, Member 3 (WNT3))

Binding Specificity: AA 155-184

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNT3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Expected species reactivity: Mouse, Chicken, Xenopus

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 155-184 from the human protein was used as the immunogen for this WNT3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the WNT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the WNT3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for WNT3

Target: WNT3 (Wingless-Type MMTV Integration Site Family, Member 3 (WNT3))

Alternative Name: WNT3 (WNT3 Products)

Synonyms: INT4 antibody, Ci-Wnt3 antibody, WNT3 antibody, int4 antibody, Xwnt3 antibody, wnt-3 antibody, wnt3l antibody, Xwnt-3 antibody, wnt3 antibody, Int-4 antibody, Wnt-3 antibody, wnt3-A antibody, Wnt family member 3 antibody, wingless-type MMTV integration site family, member 3 antibody, proto-oncogene Wnt-3 antibody, wingless-type MMTV integration site family member 3 antibody, Wnt family member 3A antibody, wingless-type MMTV integration site family member 3 L homeolog antibody, WNT3 antibody, Wnt3 antibody, wnt3 antibody, LOC468297 antibody, WNT3A antibody, wnt3.L antibody

Background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98 % amino acid identity to mouse Wnt3 protein, and 84 % to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.

UniProt: P56703

Pathways: WNT Signaling, Regulation of Cell Size