FOXL1 antibody

Catalog No. ABIN498334

Product Details anti-FOXL1 Antibody

Target: FOXL1 (Forkhead Box L1 (FOXL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of FoxL1 protein. (region surrounding Gly150)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for FOXL1

Target: FOXL1 (Forkhead Box L1 (FOXL1))

Alternative Name: FOXL1 / FKHL11 (FOXL1 Products)

Synonyms: zgc:63595 antibody, FOXL1 antibody, fkh6 antibody, fkhl11 antibody, freac7 antibody, CG1132 antibody, Dmel\\CG1132 antibody, Dmfd2 antibody, FD2 antibody, FoxL1 antibody, fd2 antibody, Foxl1 antibody, FKH6 antibody, FKHL11 antibody, FREAC7 antibody, Fkh6 antibody, fkh-6 antibody, forkhead box L1 antibody, forkhead domain 64A antibody, forkhead transcription factor L1 antibody, forkhead box L1 transcription factor antibody, foxl1 antibody, FOXL1 antibody, fd64A antibody, LOC579718 antibody, Foxl1 antibody

Background: FOXL1 is a 337 amino acid protein encoded by the mouse gene Foxl1. FOXL1 belongs to the fork head family and contains one fork head DNA-binding domain. The HNF3/fork head family includes a large number of transcription factors that share a structurally related DNA binding domain. Fork head factors are known to play important roles both during development and in adults. FOXL1 is a winged helix transcriptional regulator expressed in the mesenchymal layer of developing and mature gastrointestinal tract. FOXL1- deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of FOXL1-deficient mice, the formation of Peyer's patches is affected, particularly in the caudal region. FOXL1 is a mesenchymal modifier of the adenomatous polyposis coli (APC) gene products and plays a key role in gastrointestinal tumorigenesis.Synonyms: FREAC7, Forkhead box protein L1, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7

Molecular Weight: approx. 36 kDa

Gene ID: 2300

NCBI Accession: NP_005241

UniProt: Q12952