LI Cadherin antibody

Catalog No. ABIN498374

Product Details anti-LI Cadherin Antibody

Target: LI Cadherin

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LI Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of LIcadherin protein. (region surrounding Thr363)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for LI Cadherin

Target: LI Cadherin

Alternative Name: Cadherin-17 (LI Cadherin Products)

Synonyms: CDH16 antibody, HPT-1 antibody, HPT1 antibody, HPT-1/LI antibody, cb903 antibody, fb65d02 antibody, wu:fb65d02 antibody, cadherin-17 antibody, cadherin 17 antibody, cadherin 17, LI cadherin (liver-intestine) antibody, CDH17 antibody, Cdh17 antibody, cdh17 antibody

Background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin beta, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.Synonyms: CDH17, HPT-1, HPT1, Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin

Molecular Weight: approx. 90 kDa

Gene ID: 1015

NCBI Accession: NP_001138135

UniProt: Q12864