FES antibody
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- Target See all FES Antibodies
- FES (Feline Sarcoma Oncogene (FES))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FES antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- This antibody detects endogenous levels of Fes protein. (region surrounding Lys161)
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, Mouse.
- Purification
- Affinity chromatography
- Purity
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product FES Primary Antibody
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- Application Notes
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- FES (Feline Sarcoma Oncogene (FES))
- Alternative Name
- C-Fes (FES Products)
- Synonyms
- FPS antibody, RGD1564385 antibody, AI586313 antibody, BB137047 antibody, c-fes antibody, FES antibody, c-fps antibody, FES proto-oncogene, tyrosine kinase antibody, feline sarcoma oncogene antibody, FES antibody, Fes antibody, fes antibody
- Background
- FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex.Synonyms: FES, FPS, Proto-oncogene c-Fps, Proto-oncogene tyrosine-protein kinase Fes/Fps
- Molecular Weight
- approx. 80 kDa
- Gene ID
- 2242
- NCBI Accession
- NP_001996
- UniProt
- P07332
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Signaling Events mediated by VEGFR1 and VEGFR2
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