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PIK3CA antibody
PIK3CA
Reactivity: Human, Mouse
WB, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PIK3CA Antibody
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Target
See all PIK3CA Antibodies
PIK3CA
(Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
Reactivity
All reactivities for PIK3CA antibodies
Human, Mouse
Host
All hosts for PIK3CA antibodies
Rabbit
Clonality
All clonalities for PIK3CA antibodies
Polyclonal
Conjugate
All conjugates for PIK3CA antibodies
This PIK3CA antibody is un-conjugated
Application
All applications for PIK3CA antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody detects endogenous levels of PI 3-kinase p110alpha protein. (region surrounding Arg519)
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
Top Product
Discover our top product PIK3CA Primary Antibody
Alternatives
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anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 961-1068) antibody
PIK3CA
Reactivity: Human, Mouse, Rat, Cow, Rabbit
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for PIK3CA
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Target
PIK3CA
(Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
Alternative Name
PIK3CA (PIK3CA Products )
Synonyms
CLOVE antibody, CWS5 antibody, MCAP antibody, MCM antibody, MCMTC antibody, PI3K antibody, p110-alpha antibody, C-P3K antibody, PI3-kinase antibody, PI3K-alpha antibody, pi3-k antibody, pi3k antibody, AA414921 antibody, C530050K14 antibody, p50alpha antibody, p55alpha antibody, p85alpha antibody, 6330412C24Rik antibody, caPI3K antibody, p110 antibody, p110alpha antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha antibody, Phosphoinositide-3-kinase, catalytic, alpha polypeptide antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha antibody, phosphoinositide-3-kinase regulatory subunit 1 antibody, PIK3CA antibody, GL50803_14855 antibody, pik3ca antibody, Pik3ca antibody, Pik3r1 antibody
Background
Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of 85 kDa (p85) and 110 kDa (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85alpha and p85beta), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110alpha and p110beta interact with p85alpha, and p110alpha has also been shown to interact with p85beta in vitro. p110delta expression is restricted to white blood cells. It has been shown to bind p85alpha and beta, but it apparently does not phosphorylate these subunits. p110delta seems to have the capacity to autophosphorylate. p110gamma does not interact with the p85 subunits. It has been shown to be activated by alpha and beta-gamma heterotrimeric G proteins.Synonyms: 5-bisphosphate 3-kinase catalytic subunit alpha isoform, EC=2.7.1.153, PI3-kinase p110 subunit alpha, PI3K, PIK3CA, Phosphatidylinositol-4, PtdIns-3-kinase p110
Molecular Weight
approx. 110 kDa
Gene ID
5290
NCBI Accession
NP_006209
UniProt
P42336
Pathways
PI3K-Akt Signaling , RTK Signaling , TCR Signaling , AMPK Signaling , Interferon-gamma Pathway , TLR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Inositol Metabolic Process , Hepatitis C , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , VEGFR1 Specific Signals , VEGF Signaling
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