Activin A Receptor Type IB/ALK-4 antibody (C-Term)

Catalog No. ABIN499207

Product Details anti-Activin A Receptor Type IB/ALK-4 Antibody

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Activin A Receptor Type IB/ALK-4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to ACVR1B near the carboxy terminus.

Purification: Affinity chromatography purified via peptide column

Immunogen: ACVR1B antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human ACVR1B.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: ACVR1B antibody can be used for detection of ACVR1B at 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Activin A Receptor Type IB/ALK-4

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Alternative Name: Activin Receptor Type 1B (ACVR1B) (ACVR1B Products)

Synonyms: ACVR1B antibody, alk4 antibody, skr2 antibody, alk-4 antibody, xalk4 antibody, actrib antibody, acvrlk4 antibody, DKFZp469A1614 antibody, 6820432J04 antibody, ActR-IB antibody, ActRIB antibody, Acvrlk4 antibody, Alk4 antibody, SKR2 antibody, ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, Skr2 antibody, axis antibody, taram-a antibody, tarama antibody, wu:fb75f01 antibody, activin A receptor type 1B antibody, Activin receptor type-1B antibody, activin A receptor, type IB antibody, activin A receptor, type 1B antibody, activin A receptor type 1Ba antibody, ACVR1B antibody, acvr1b antibody, acv1b antibody, Acvr1b antibody, acvr1ba antibody

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions. At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.Synonyms: ACTR-IB, ACVRLK4, ALK4, Activin receptor type IB, Activin receptor-like kinase 4, SKR2, Serine/threonine-protein kinase receptor R2

Gene ID: 91

NCBI Accession: NP_004293

UniProt: P36896