Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Caspase 4 antibody (Caspase 4, Apoptosis-Related Cysteine Peptidase) (N-Term) Primary Antibody

CASP4 Reactivity: Human, Mouse EIA, IF, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499561
$598.40
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Available
  • Target
    Caspase 4 (CASP4)
    Binding Specificity
    • 11
    • 10
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 81
    • 34
    • 18
    • 15
    • 2
    Human, Mouse
    Host
    • 92
    • 11
    • 7
    • 3
    • 1
    Rabbit
    Clonality
    • 99
    • 14
    Polyclonal
    Conjugate
    • 64
    • 18
    • 11
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Caspase 4 antibody is un-conjugated
    Application
    • 101
    • 44
    • 39
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Specificity
    This antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-4.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human Casp-4 / ICH-2 / ICE rel II / Mih1 (N-Terminus) Peptide
    Isotype
    IgG
  • Application Notes
    ELISA. Western Blot: Casp-4 antibody can be used for the detection of Caspase-4 at 1 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Caspase 4 (CASP4)
    Alternative Name
    Caspase-4 (CASP4 Antibody Abstract)
    Synonyms
    ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX, Casp11, CASP13, CASP1, CASP4, Caspl, ich-3, Casp4, caspase 4, caspase 4, apoptosis-related cysteine peptidase, caspase-4, CASP4, Casp4, LOC100731032
    Background
    Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease (5).Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
    Gene ID
    837
    UniProt
    P49662
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
You are here:
help Support