IL-21 antibody (Intermediate Domain)

Catalog No. ABIN499986

The Rabbit Polyclonal anti-IL-21 antibody (ABIN499986) specifically detects IL-21 in WB, IF and EIA. The antibody is reactive with Human samples.

Quick Overview for IL-21 antibody (Intermediate Domain) (ABIN499986)

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-21 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-IL-21 Antibody

Binding Specificity: Intermediate Domain

Specificity: IL-21 antibody was raised against a synthetic peptide corresponding to 15 amino acids near the center of human IL-21 precursor.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human IL-21 (Intermediate Domain) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 0.5 to 1 μg/mL. An approximately 18 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Alternative Name: Interleukin-21 / IL21

Background: A novel cytokine was recently identified in human and mouse and designated IL-21 , which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.Synonyms: IL-21, Za11

Gene ID: 59067

NCBI Accession: NP_068575

UniProt: Q9HBE4

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response