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Complexin 1 antibody (AA 31-100) (AbBy Fluor® 680)

CPLX1 Reactivity: Mouse, Rat WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 680
Catalog No. ABIN5000461
  • Target See all Complexin 1 (CPLX1) Antibodies
    Complexin 1 (CPLX1)
    Binding Specificity
    • 14
    • 14
    • 8
    • 7
    • 6
    • 6
    • 1
    • 1
    AA 31-100
    Reactivity
    • 36
    • 25
    • 23
    Mouse, Rat
    Host
    • 49
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 52
    Polyclonal
    Conjugate
    • 15
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Complexin 1 antibody is conjugated to AbBy Fluor® 680
    Application
    • 36
    • 22
    • 20
    • 12
    • 12
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Cow,Pig,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CPLX1
    Isotype
    IgG
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    Discover our top product CPLX1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Complexin 1 (CPLX1)
    Alternative Name
    CPLX1 (CPLX1 Products)
    Synonyms
    MGC84299 antibody, CPLX1 antibody, CPX-I antibody, CPX1 antibody, 921-S antibody, complexin 1 L homeolog antibody, complexin 1 antibody, cplx1.L antibody, CPLX1 antibody, cplx1 antibody, Cplx1 antibody
    Background

    Synonyms: complexin 1, Complexin I, Complexin-1, CPLX1, CPLX1_HUMAN, CPX I, CPX-I, CPX1, Synaphin 2, Synaphin-2, 921-S.

    Background: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.

    Pathways
    Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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