Peroxiredoxin 2 antibody (AA 131-198) (Alexa Fluor 750)
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- Target See all Peroxiredoxin 2 (PRDX2) Antibodies
- Peroxiredoxin 2 (PRDX2)
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Binding Specificity
- AA 131-198
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Peroxiredoxin 2 antibody is conjugated to Alexa Fluor 750
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Application
- Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Rat
- Predicted Reactivity
- Mouse,Dog,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Peroxiredoxin-2
- Isotype
- IgG
- Top Product
- Discover our top product PRDX2 Primary Antibody
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- Application Notes
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Peroxiredoxin 2 (PRDX2)
- Alternative Name
- Peroxiredoxin 2 (PRDX2 Products)
- Synonyms
- NKEF-B antibody, NKEFB antibody, PRP antibody, PRX2 antibody, PRXII antibody, PTX1 antibody, TDPX1 antibody, TPX1 antibody, TSA antibody, AL022839 antibody, Band-8 antibody, NkefB antibody, PrxII antibody, TDX1 antibody, TPx antibody, TPx-B antibody, TR antibody, Tdpx1 antibody, Torin antibody, nkefb antibody, prx-2 antibody, prx2 antibody, prxii antibody, tdpx1 antibody, tpx1 antibody, peroxiredoxin 2 antibody, peroxiredoxin 2 L homeolog antibody, PRDX2 antibody, Prdx2 antibody, prdx2.L antibody
- Background
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Synonyms: MGC4104, Natural killer cell enhancing factor B, Natural killer cell-enhancing factor B, Natural Killer Enhancing Factor B, NKEF B, NKEF-B, NKEFB, Peroxiredoxin-2, PRDX 2, PRDX2, PRDX2_HUMAN, PRP, PRX2, PRXII, TDPX1, Thiol Specic Antioxidant 1, Thiol specic antioxidant protein, Thiol-specic antioxidant protein, Thioredoxin Dependent Peroxide Reductase 1, Thioredoxin Peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Torin, TPX1, TSA.
Background: Peroxiredoxin (Prx) is an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at the active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Peroxiredoxin 1 to 4 have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Peroxiredoxin 1. The active site cysteine(Cys51) is oxidized to cysteine sulfenic acid(Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from the other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress conditions, the sulfenic intermediate(Cys51-SOH) can be easily over oxidized to cysteine sulfinic acid(Cys-SO2H) or cysteine sulfonic acid(Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that over oxidized Prx can be reduced back to the active form during recovery after oxidative stress.
- Gene ID
- 7001
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