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MYD88 antibody (AA 1-200)
MYD88
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MYD88 Antibody
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Target
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MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Binding Specificity
All epitopes for MYD88 antibodies
AA 1-200
Reactivity
All reactivities for MYD88 antibodies
Human
Host
All hosts for MYD88 antibodies
Rabbit
Clonality
All clonalities for MYD88 antibodies
Polyclonal
Conjugate
All conjugates for MYD88 antibodies
This MYD88 antibody is un-conjugated
Application
All applications for MYD88 antibodies
Western Blotting (WB)
Purification
Protein A Chromatography
Immunogen
A partial length recombinant MyD88 protein (amino acids 1-200) was used as the immunogen for this antibody.
Isotype
IgG
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Application Details
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Application Notes
WB: 4-6 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for MYD88
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Target
MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Alternative Name
MyD88 (MYD88 Products )
Synonyms
MYD88D antibody, XMyD88 antibody, myd88d antibody, MGC84928 antibody, CG2078 antibody, DMMYD88 antibody, DmMyD88 antibody, DmMyd88 antibody, Dmel\\CG2078 antibody, EP(2)2535 antibody, Kra antibody, LD20892 antibody, MYD88 antibody, MyD88 antibody, Myd88F antibody, dMyD88 antibody, dMyd88 antibody, kra antibody, myd88 antibody, zgc:103541 antibody, GB12344 antibody, NV10640 antibody, myd88-a antibody, myd88-b antibody, myeloid differentiation primary response 88 antibody, myeloid differentiation primary response 88 S homeolog antibody, myeloid differentiation primary response gene 88 antibody, CG2078 gene product from transcript CG2078-RB antibody, myeloid differentiation primary response protein MyD88-A antibody, myeloid differentiation primary response protein MyD88 antibody, myeloid differentiation factor 88 antibody, myeloid differentiation primary response 88 L homeolog antibody, MYD88 antibody, myd88.S antibody, Myd88 antibody, myd88 antibody, LOC413194 antibody, LOC100118553 antibody, LOC575153 antibody, myd88.L antibody
Background
MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.
Molecular Weight
32 kDa
Gene ID
4615
UniProt
Q99836
Pathways
NF-kappaB Signaling , TLR Signaling , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Toll-Like Receptors Cascades
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