SWAP70 antibody (AA 300-505)

Catalog No. ABIN5027555

Product Details anti-SWAP70 Antibody

Target: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Binding Specificity: AA 300-505

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SWAP70 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant SWAP70 protein (amino acids 300-505) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for SWAP70

Target: SWAP70 (SWAP Switching B-Cell Complex 70kDa Subunit (SWAP70))

Alternative Name: SWAP70 (SWAP70 Products)

Synonyms: SWAP-70 antibody, 70kDa antibody, AV235546 antibody, HSPC321 antibody, swap70b antibody, zgc:63599 antibody, switching B-cell complex subunit SWAP70 antibody, SWA-70 protein antibody, SWAP switching B-cell complex 70 antibody, SWAP switching B-cell complex 70kDa subunit antibody, switching B-cell complex subunit SWAP70a antibody, SWAP70 antibody, Swap70 antibody, swap70 antibody, swap70a antibody

Background: SWAP-70 is a 70 kDa multiple functional signaling proteins involved in formation of membrane ruffling induced by signal cascade of tyrosine kinase growth factor receptors. It is involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates. Though originally isolated from activated B lymphocytes, recently it has been found that it is widely expressed in various cell types and tissues. It has a high binding afinity to PI(3,4)P2. Its intracellular localization has been reported to depend on cell activation. Stimulation of the B cell receptor triggers a translocation of SWAP-70 from the cytosol to the plasma membrane in B cells. This translocation required a functional PH-domain. SWAP-70 functions as the only B cell-specific component of an isotype switch recombination complex called SWAP. The SWAP complex has specificity for the switch regions upstream of the constant region immunoglobulin genes and it facilitates the transfer of DNA between switch regions. These features suggested that mutations in the gene encoding SWAP-70 might result in humoral immunodeficiency.

Molecular Weight: 64 kDa

Gene ID: 23075

UniProt: Q9UH65

Pathways: Production of Molecular Mediator of Immune Response