SPIB antibody

Catalog No. ABIN5027786

Product Details anti-SPIB Antibody

Target: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPIB antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: Full length recombinant SpiB protein was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for SPIB

Target: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Alternative Name: SpiB (SPIB Products)

Synonyms: spi-b antibody, spib antibody, spiba antibody, SPI-B antibody, B42b-like antibody, Spi-B antibody, Spi-B transcription factor L homeolog antibody, Spi-B transcription factor antibody, Spi-B transcription factor (Spi-1/PU.1 related) antibody, spib.L antibody, SPIB antibody, Spib antibody

Background: Spi-B belongs to the ETS family transcription factor containing a conserved ETS domain which specifically binds to a purine-rich DNA sequence called the PU-box (5'-GAGGAA-3'). Spi-B has two known isoforms (28 and 18 kDa) and is localized in nucleus and cytoplasm. Spi-B contains two transactivation domains (TAD) at the N-terminal end which may be required for transcriptional activation of the target genes. Spi-B is involved in development of plasmacytoid dendritic cells (natural interferon producing cells) and B-cell development. Spi-B acts as a lymphoid specific enhancer. Spi-B is highly expressed in plasmacytoid dendritic cells (pDCs), B-cells and stem cell populations of the liver.

Molecular Weight: 28 kDa

Gene ID: 6689

UniProt: Q01892