EPM2A antibody (AA 243-331)

Catalog No. ABIN533790

Product Details anti-EPM2A Antibody

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Binding Specificity: AA 243-331

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPM2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Purpose: Mouse monoclonal antibody raised against partial recombinant EPM2A.

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: Recombinant protein corresponding to amino acids 243-331 of human EPM2A.

Clone: K2A3

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS, pH 7.4 (10 % glycerol, 0.02 % sodium azide).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-EPM2A antibody (ABIN533790)

Tagliabracci, Turnbull, Wang, Girard, Zhao, Skurat, Delgado-Escueta, Minassian, Depaoli-Roach, Roach: "Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 49, pp. 19262-6, (2007) (PubMed).

Wang, Parker, Skurat, Raben, DePaoli-Roach, Roach: "Relationship between glycogen accumulation and the laforin dual specificity phosphatase." in: Biochemical and biophysical research communications, Vol. 350, Issue 3, pp. 588-92, (2006) (PubMed).

Ganesh, Delgado-Escueta, Suzuki, Francheschetti, Riggio, Avanzini, Rabinowicz, Bohlega, Bailey, Alonso, Rasmussen, Thomson, Ochoa, Prado, Medina, Yamakawa: "Genotype-phenotype correlations for EPM2A mutations in Lafora's progressive myoclonus epilepsy: exon 1 mutations associate with an early-onset cognitive deficit subphenotype." in: Human molecular genetics, Vol. 11, Issue 11, pp. 1263-71, (2002) (PubMed).

Target Details for EPM2A

Target: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Alternative Name: Laforin (EPM2A Products)

Synonyms: TG-B antibody, Tg(TcraK,TcrbK)TG-BFlv antibody, EPM2 antibody, MELF antibody, laforin antibody, EPM2A, laforin glucan phosphatase antibody, epilepsy, progressive myoclonic epilepsy, type 2 gene alpha antibody, EPM2A antibody, Epm2a antibody

Gene ID: 7957

Pathways: Cellular Glucan Metabolic Process