FCGR3A antibody (PE)

Catalog No. ABIN535935

Product Details anti-FCGR3A Antibody (PE)

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCGR3A antibody is conjugated to PE

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Purpose: Mouse monoclonal antibody raised against native FCGR3A.

Specificity: This antibody reacts with CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA, 50-65 KDa, expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB, 48 KDa, mainly expressed on neutrophils).

Cross-Reactivity: Human, Non-Human Primate

Immunogen: Native purified FCGR3A from normal human peripheral blood granulocytes.

Clone: LNK16

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (20 µL in human blood cells 100 µL in whole blood or 10⁶ cells in a suspension)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.2 % BSA, 0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.

References for anti-FCGR3A antibody (PE) (ABIN535935)

Boyle: "Human macrophages kill human mesangial cells by Fas-L-induced apoptosis when triggered by antibody via CD16." in: Clinical and experimental immunology, Vol. 137, Issue 3, pp. 529-37, (2004) (PubMed).

Arase, Arase, Hirano, Yokosuka, Sakurai, Saito: "IgE-mediated activation of NK cells through Fc gamma RIII." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 6, pp. 3054-8, (2003) (PubMed).

Target Details for FCGR3A

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Alternative Name: FCGR3A (FCGR3A Products)

Synonyms: CD16 antibody, CD16A antibody, FCG3 antibody, FCGR3 antibody, FCGRIII antibody, FCR-10 antibody, FCRIII antibody, FCRIIIA antibody, IGFR3 antibody, Fcgr4 antibody, Fc fragment of IgG receptor IIIa antibody, FCGR3A antibody, Fcgr3a antibody

Gene ID: 2214