DcR1 antibody (AA 1-280) (PE)

Catalog No. ABIN536703

Product Details anti-DcR1 Antibody (PE)

Target: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Binding Specificity: AA 1-280

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DcR1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purpose: Mouse monoclonal antibody raised against recombinant TNFRSF10C.

Specificity: This antibody reacts with TRAIL-R3, a 35 KDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.

Cross-Reactivity: Human

Immunogen: Recombinant Fc fusion protein corresponding to amino acids 1-280 of TNFRSF10C.

Clone: TRAIL-R3-02

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (3 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: In PBS (0.2 % BSA, 0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.

References for anti-DcR1 antibody (PE) (ABIN536703)

Mérino, Lalaoui, Morizot, Schneider, Solary, Micheau: "Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2." in: Molecular and cellular biology, Vol. 26, Issue 19, pp. 7046-55, (2006) (PubMed).

Sanlioglu, Dirice, Aydin, Erin, Koksoy, Sanlioglu: "Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells." in: BMC cancer, Vol. 5, pp. 54, (2005) (PubMed).

Clancy, Mruk, Archer, Woelfel, Mongkolsapaya, Screaton, Lenardo, Chan: "Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 50, pp. 18099-104, (2005) (PubMed).

Target Details for DcR1

Target: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Alternative Name: CD263 / TRAILR3 (TNFRSF10C Products)

Synonyms: CD263 antibody, DCR1 antibody, DCR1-TNFR antibody, LIT antibody, TRAIL-R3 antibody, TRAILR3 antibody, TRID antibody, TNFRSF10C antibody, TNF receptor superfamily member 10c antibody, TNFRSF10C antibody

Gene ID: 8794

Pathways: Apoptosis