EZH2 antibody (AA 1-343)

Catalog No. ABIN537794

Product Details anti-EZH2 Antibody

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Binding Specificity: AA 1-343

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EZH2 antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Purpose: Rabbit polyclonal antibody raised against partial recombinantt Ezh2.

Cross-Reactivity: Mouse

Immunogen: Recombinant protein corresponding to amino acids 1-343 of the mouse EZH2.

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.05 % sodium azide, 0.05 % proclin 300)

Preservative: ProClin, Sodium azide

Precaution of Use: This product contains ProClin and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-EZH2 antibody (ABIN537794)

Mathiyalagan, Okabe, Chang, Su, Du, El-Osta: "The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart." in: Nucleic acids research, Vol. 42, Issue 2, pp. 790-803, (2014) (PubMed).

Rugg-Gunn, Cox, Ralston, Rossant: "Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 24, pp. 10783-90, (2010) (PubMed).

Kuzmichev, Margueron, Vaquero, Preissner, Scher, Kirmizis, Ouyang, Brockdorff, Abate-Shen, Farnham, Reinberg: "Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 6, pp. 1859-64, (2005) (PubMed).

Kleer, Cao, Varambally, Shen, Ota, Tomlins, Ghosh, Sewalt, Otte, Hayes, Sabel, Livant, Weiss, Rubin, Chinnaiyan: "EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11606-11, (2003) (PubMed).

Varambally, Dhanasekaran, Zhou, Barrette, Kumar-Sinha, Sanda, Ghosh, Pienta, Sewalt, Otte, Rubin, Chinnaiyan: "The polycomb group protein EZH2 is involved in progression of prostate cancer." in: Nature, Vol. 419, Issue 6907, pp. 624-9, (2002) (PubMed).

Target Details for EZH2

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Alternative Name: EZH2 / KMT6 (EZH2 Products)

Synonyms: ENX-1 antibody, ENX1 antibody, EZH1 antibody, EZH2b antibody, KMT6 antibody, KMT6A antibody, WVS antibody, WVS2 antibody, eya2 antibody, im:7149338 antibody, zgc:136376 antibody, zgc:152758 antibody, EZH2 antibody, enx-1 antibody, enx1 antibody, ezh1 antibody, kmt6 antibody, xez antibody, Enx-1 antibody, Enx1h antibody, mKIAA4065 antibody, ezh2 antibody, olezh2 antibody, enhancer of zeste 2 polycomb repressive complex 2 subunit antibody, enhancer of zeste 2 polycomb repressive complex 2 subunit L homeolog antibody, enhancer of zeste 2 polycomb repressive complex 2 subunit S homeolog antibody, EZH2 antibody, ezh2 antibody, Ezh2 antibody, ezh2.L antibody, ezh2.S antibody

Gene ID: 14056

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation