EGLN1 antibody (AA 350-426)

Catalog No. ABIN540735

Product Details anti-EGLN1 Antibody

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Binding Specificity: AA 350-426

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGLN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of EGLN1.

Specificity: This antibody is specific to human HIF prolyl hydroxylase 2. There is 83 % homology between the immunogen used for this antibody and the rat and mouse proteins.

Cross-Reactivity: Human

Immunogen: A synthetic peptide corresponding to amino acids 350-426 of human EGLN1.

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

References for anti-EGLN1 antibody (ABIN540735)

Wong, Goehring, Kapiloff, Langeberg, Scott: "mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha." in: Science signaling, Vol. 1, Issue 51, pp. ra18, (2008) (PubMed).

Colla, Tagliaferri, Morandi, Lunghi, Donofrio, Martorana, Mancini, Lazzaretti, Mazzera, Ravanetti, Bonomini, Ferrari, Miranda, Ladetto, Neri, Neri, Greco, Mangoni, Bonati, Rizzoli, Giuliani et al.: "The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha ..." in: Blood, Vol. 110, Issue 13, pp. 4464-75, (2007) (PubMed).

Ietta, Wu, Winter, Xu, Wang, Post, Caniggia: "Dynamic HIF1A regulation during human placental development." in: Biology of reproduction, Vol. 75, Issue 1, pp. 112-21, (2006) (PubMed).

Baek, Mahon, Oh, Kelly, Krishnamachary, Pearson, Chan, Giaccia, Semenza: "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha." in: Molecular cell, Vol. 17, Issue 4, pp. 503-12, (2005) (PubMed).

Target Details for EGLN1

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Alternative Name: EGLN1 / PHD2 (EGLN1 Products)

Synonyms: EGLN1 antibody, egln2 antibody, phd2 antibody, zgc:92314 antibody, AI503754 antibody, C1orf12 antibody, HIF-PH2 antibody, HPH-2 antibody, Hif-p4h-2 antibody, ORF13 antibody, Phd2 antibody, SM-20 antibody, PHD-2 antibody, PHD2 antibody, ECYT3 antibody, HIFPH2 antibody, HPH2 antibody, SM20 antibody, ZMYND6 antibody, egl nine homolog 1 (C. elegans) antibody, egl-9 family hypoxia inducible factor 1 antibody, egl-9 family hypoxia-inducible factor 1 S homeolog antibody, egl-9 family hypoxia-inducible factor 1b antibody, egl-9 family hypoxia-inducible factor 1 antibody, EGLN1 antibody, egln1.S antibody, egln1b antibody, Egln1 antibody

Gene ID: 54583

Pathways: cAMP Metabolic Process, Warburg Effect