UNC93B1 antibody (N-Term)

Catalog No. ABIN541343

Product Details anti-UNC93B1 Antibody

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC93B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of UNC93B1.

Cross-Reactivity: Human, Mouse, Rat

Immunogen: A synthetic peptide corresponding to N-terminus 19 amino acids of human UNC93B1.

Application Details

Application Notes: Western Blot (0.5-1 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-UNC93B1 antibody (ABIN541343)

Panchanathan, Liu, Choubey: "Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity." in: International immunology, Vol. 25, Issue 9, pp. 521-9, (2013) (PubMed).

Brinkmann, Spooner, Hoebe, Beutler, Ploegh, Kim: "The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling." in: The Journal of cell biology, Vol. 177, Issue 2, pp. 265-75, (2007) (PubMed).

Tabeta, Hoebe, Janssen, Du, Georgel, Crozat, Mudd, Mann, Sovath, Goode, Shamel, Herskovits, Portnoy, Cooke, Tarantino, Wiltshire, Steinberg, Grinstein, Beutler: "The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9." in: Nature immunology, Vol. 7, Issue 2, pp. 156-64, (2006) (PubMed).

Liu, Dodds, Emilion, Mungall, Dunham, Beck, Wells, Charnock, Ganesan: "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer." in: BMC genetics, Vol. 3, pp. 20, (2002) (PubMed).

Target Details for UNC93B1

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Alternative Name: UNC93B1 (UNC93B1 Products)

Synonyms: UNC93 antibody, IIAE1 antibody, UNC93B antibody, Unc-93B1 antibody, Unc93b antibody, unc-93 homolog B1, TLR signaling regulator antibody, unc-93 homolog B1 (C. elegans) antibody, UNC93B1 antibody, Unc93b1 antibody

Gene ID: 81622

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades