NOTCH3 antibody (C-Term)

Catalog No. ABIN542946

Product Details anti-NOTCH3 Antibody

Target: NOTCH3 (Notch 3 (NOTCH3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of NOTCH3.

Cross-Reactivity: Human

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human NOTCH3.

Application Details

Application Notes: Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-NOTCH3 antibody (ABIN542946)

Suwanwela, Srikiatkhachorn, Tangwongchai, Phanthumchina, Suwanwela: "Mutation of the Notch 3 gene in a Thai cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy family." in: Journal of the Medical Association of Thailand = Chotmaihet thangphaet, Vol. 86, Issue 2, pp. 178-82, (2003) (PubMed).

Ahearn, Speer, Chen, Steffens, Cassidy, Van Meter, Provenzale, Weisler, Krishnan: "Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype." in: American journal of medical genetics, Vol. 114, Issue 6, pp. 652-8, (2002) (PubMed).

Bellavia, Campese, Checquolo, Balestri, Biondi, Cazzaniga, Lendahl, Fehling, Hayday, Frati, von Boehmer, Gulino, Screpanti: "Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 6, pp. 3788-93, (2002) (PubMed).

Target Details for NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Alternative Name: NOTCH3 (NOTCH3 Products)

Synonyms: CADASIL antibody, CASIL antibody, IMF2 antibody, AW229011 antibody, N3 antibody, hpbk antibody, fa14b08 antibody, notch5 antibody, wu:fa14b08 antibody, notch 3 antibody, NOTCH3 antibody, Notch3 antibody, notch3 antibody

Gene ID: 4854

Pathways: Notch Signaling