Cadherin 5 antibody (AA 770-781)

Catalog No. ABIN548418

Product Details anti-Cadherin 5 Antibody

Target: Cadherin 5 (CDH5)

Binding Specificity: AA 770-781

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of CDH5.

Specificity: This sequence has significant homology to the conserved site in rat and mouse, and has less than 50 % homology with other cadherins.

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: A synthetic peptide corresponding to amino acids 770-781 of human CDH5.

Application Details

Application Notes: ELISA (1:2000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (50 % glycerol, 1 mg/mL BSA, 0.05 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-Cadherin 5 antibody (ABIN548418)

Wallez, Cand, Cruzalegui, Wernstedt, Souchelnytskyi, Vilgrain, Huber: "Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site." in: Oncogene, Vol. 26, Issue 7, pp. 1067-77, (2007) (PubMed).

Potter, Barbero, Cheresh: "Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state." in: The Journal of biological chemistry, Vol. 280, Issue 36, pp. 31906-12, (2005) (PubMed).

Baumeister, Funke, Ebnet, Vorschmitt, Koch, Vestweber: "Association of Csk to VE-cadherin and inhibition of cell proliferation." in: The EMBO journal, Vol. 24, Issue 9, pp. 1686-95, (2005) (PubMed).

Target Details for Cadherin 5

Target: Cadherin 5 (CDH5)

Alternative Name: CD144 / Cadherin-5 (CDH5 Products)

Synonyms: 7B4 antibody, AA408225 antibody, Cd144 antibody, VE-Cad antibody, VECD antibody, VEcad antibody, Vec antibody, wu:fc88a07 antibody, CD144 antibody, cadherin-5 antibody, cadherin 5 antibody, CDH5 antibody, Cdh5 antibody, cdh5 antibody

Gene ID: 1003

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2