NUDT1 antibody (Middle Region)

Catalog No. ABIN5514381

Product Details anti-NUDT1 Antibody

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDT1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: WNGFGGKVQE GETIEDGARR ELQEESGLTV DALHKVGQIV FEFVGEPELM

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against 8ODP. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human 8ODP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NUDT1

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Alternative Name: 8ODP (NUDT1 Products)

Synonyms: mutT antibody, nudT1 antibody, MTH1 antibody, Mth1 antibody, 7,8-dihydro-8-oxoguanine triphosphatase antibody, nudix hydrolase 1 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 1 antibody, mth1 antibody, Tsp_07498 antibody, nudt1 antibody, 8odp antibody, NUDT1 antibody, Nudt1 antibody

Background: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Alias Symbols: NUDT1, MTH1,

Protein Interaction Partner: ACY1, UBC, DCUN1D1, COPS5, COPS6, CUL1, CUL2, CUL4B, CUL5, CAND1, RNMTL1, NTHL1,

Protein Size: 197

Gene ID: 4521

UniProt: P36639