C14orf169 + NO66 antibody (Middle Region)

Catalog No. ABIN5514591

Product Details anti-C14orf169 + NO66 Antibody

Target: C14orf169 + NO66 (C14orf169) (Chromosome 14 Open Reading Frame 169 (C14orf169))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C14orf169 + NO66 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EAILPLAVQA AMEENVEFRR GLPRDFMDYM GAQHSDSKDP RRTAFMEKVR

Characteristics: This is a rabbit polyclonal antibody against NO66. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human NO66

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for C14orf169 + NO66

Target: C14orf169 + NO66 (C14orf169) (Chromosome 14 Open Reading Frame 169 (C14orf169))

Alternative Name: NO66 (C14orf169 Products)

Synonyms: LOC453015 antibody, C10H14orf169 antibody, MAPJD antibody, NO66 antibody, ROX antibody, C14orf169 antibody, No66 antibody, im:7141580 antibody, no66 antibody, chromosome 14 open reading frame 169 antibody, ribosomal oxygenase 1 antibody, chromosome 5 open reading frame, human C14orf169 antibody, LOC453015 antibody, Bm1_08415 antibody, RIOX1 antibody, C5H14ORF169 antibody, Riox1 antibody, riox1 antibody

Background: NO66 is an oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically It demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). It also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). It may also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region.

Alias Symbols: NO66, C14orf169, MAPJD,

Protein Interaction Partner: KAT5, TRRAP, MYC, USP42,

Protein Size: 429

Gene ID: 79697