Desmocollin 3 antibody (Middle Region)

Catalog No. ABIN5514719

Product Details anti-Desmocollin 3 Antibody

Target: Desmocollin 3 (DSC3)

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IKENLAVGSK INGYKAYDPE NRNGNGLRYK KLHDPKGWIT IDEISGSIIT

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DSC3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Desmocollin 3

Target: Desmocollin 3 (DSC3)

Alternative Name: DSC3 (DSC3 Products)

Synonyms: CDHF3 antibody, DSC antibody, DSC1 antibody, DSC2 antibody, DSC4 antibody, HT-CP antibody, 5430426I24Rik antibody, MGC85083 antibody, desmocollin 3 antibody, desmocollin 3 S homeolog antibody, DSC3 antibody, Dsc3 antibody, dsc3.S antibody, dsc3 antibody

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.

Alias Symbols: DSC, DSC1, DSC2, DSC4, CDHF3, HT-CP,

Protein Size: 839

Gene ID: 1825

NCBI Accession: NM_001941, NP_001932