HTRA2 antibody (Middle Region)

Catalog No. ABIN5514857

Product Details anti-HTRA2 Antibody

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TMKVTAGISF AIPSDRLREF LHRGEKKNSS SGISGSQRRY IGVMMLTLSP

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HTRA2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HTRA2 (HTRA2 Products)

Synonyms: CG8464 antibody, DmHtrA2 antibody, Dmel\\CG8464 antibody, HtrA2/Omi antibody, Omi antibody, dOmi antibody, domi antibody, htrA2 antibody, omi antibody, HTRA2 antibody, PRSS25 antibody, OMI antibody, PARK13 antibody, AI481710 antibody, Prss25 antibody, mnd2 antibody, HTRA2-related serine protease antibody, HtrA serine peptidase 2 antibody, HtrA2 antibody, HTRA2 antibody, htra2 antibody, Htra2 antibody

Background: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.

Alias Symbols: OMI, PARK13, PRSS25

Protein Size: 361

Gene ID: 27429

NCBI Accession: NM_013247, NP_037379

Pathways: Positive Regulation of Endopeptidase Activity