PMS1 antibody (Middle Region)

Catalog No. ABIN5515042

Product Details anti-PMS1 Antibody

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMS1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PFQNDMHNDE SGKNTDDCLN HQISIGDFGY GHCSSEISNI DKNTKNAFQD

Characteristics: This is a rabbit polyclonal antibody against PMS1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PMS1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PMS1

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Alternative Name: PMS1 (PMS1 Products)

Synonyms: PMSL1 antibody, si:dz72b14.2 antibody, si:dz164h20.2 antibody, PMS1 antibody, DKFZp468M105 antibody, pms1 antibody, HNPCC3 antibody, hPMS1 antibody, PMS1 homolog 1, mismatch repair system component antibody, PMS1 homolog 1, mismatch repair system component S homeolog antibody, PMS1 antibody, Pms1 antibody, pms1 antibody, pms1.S antibody

Background: This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.

Alias Symbols: MLH2, PMSL1, hPMS1, HNPCC3

Protein Interaction Partner: UBC, MSH6, MSH2, MLH1, FAN1, USP5, TOP1, SBF1, RFC4, RFC2, RFC1, REV3L, RANGAP1, PSMC1, PPP2R1A, PMS1, PIK3C2A, PGK1, NONO, MOV10, MCM6, IPO5, KPNA2, CYLD, CDK9, CDC5L, CCNT1, BRCA2, ATR, HELB, PSD2, BRIP1, SBF2, MMS19, RNF123, RNF20, IPO9, UBR5, AKAP9, R

Protein Size: 932

Gene ID: 5378

NCBI Accession: NM_000534, NP_000525

UniProt: P54277