C10orf2 antibody (C-Term)

Catalog No. ABIN5515466

Product Details anti-C10orf2 Antibody

Target: C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C10orf2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FRKFATDNNC HVTLVIHPRK EDDDKELQTA SIFGSAKASQ EADNVLILQD

Characteristics: This is a rabbit polyclonal antibody against PEO1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PEO1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for C10orf2

Target: C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))

Alternative Name: PEO1 (C10ORF2 Products)

Synonyms: ATXN8 antibody, IOSCA antibody, MTDPS7 antibody, PEO antibody, PEO1 antibody, PEOA3 antibody, SANDO antibody, SCA8 antibody, TWINL antibody, C6H10orf2 antibody, D19Ertd626e antibody, Twinl antibody, twinkle mtDNA helicase L homeolog antibody, twinkle mtDNA helicase antibody, twnk.L antibody, TWNK antibody, Twnk antibody

Background: This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alias Symbols: PEO1, C10orf2,

Protein Interaction Partner: ZBTB1, BMI1, SMAD9, ICT1, SQSTM1, AKTIP,

Protein Size: 684

Gene ID: 56652

NCBI Accession: NP_068602

UniProt: Q96RR1