APOBEC3A antibody (Middle Region)

Catalog No. ABIN5515787

Product Details anti-APOBEC3A Antibody

Target: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APOBEC3A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PASGPRHLMD PHIFTSNFNN GIGRHKTYLC YEVERLDNGT SVKMDQHRGF

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human APOBEC3A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APOBEC3A

Target: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Alternative Name: APOBEC3A (APOBEC3A Products)

Synonyms: A3A antibody, ARP3 antibody, PHRBN antibody, bK150C2.1 antibody, APOBEC3A antibody, APOBEC3Z1 antibody, apolipoprotein B mRNA editing enzyme catalytic subunit 3A antibody, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A antibody, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z1 antibody, similar to ARP10 protein antibody, APOBEC3A antibody, APOBEC3Z1 antibody

Background: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A, however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.

Protein Size: 199

Gene ID: 100913187

NCBI Accession: NM_001193289, NP_001180218

UniProt: P31941