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Crk antibody (Middle Region)
CRK
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Crk Antibody
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Target
See all Crk (CRK) Antibodies
Crk (CRK)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
Binding Specificity
All epitopes for Crk antibodies
Middle Region
Reactivity
All reactivities for Crk antibodies
Human
Host
All hosts for Crk antibodies
Rabbit
Clonality
All clonalities for Crk antibodies
Polyclonal
Conjugate
All conjugates for Crk antibodies
This Crk antibody is un-conjugated
Application
All applications for Crk antibodies
Western Blotting (WB)
Sequence
PVPYVEKYRP ASASVSALIG GNQEGSHPQP LGGPEPGPYA QPSVNTPLPN
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CRK
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for Crk
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Target
Crk (CRK)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
Alternative Name
CRK (CRK Products )
Synonyms
CG1587 antibody, CRK antibody, D-CRK antibody, D-Crk antibody, DCrk antibody, Dcrk antibody, Dmel\\CG1587 antibody, crk antibody, dCRK antibody, dCrk antibody, fb34h10 antibody, fc05a01 antibody, fi19g05 antibody, wu:fb34h10 antibody, wu:fc05a01 antibody, wu:fc54a04 antibody, wu:fi19g05 antibody, zgc:100936 antibody, CRKII antibody, p38 antibody, Crko antibody, crk2 antibody, crkII antibody, v-crk antibody, P38C-CRK antibody, Crk-I antibody, Crk-II antibody, Crk-III antibody, Crk3 antibody, CrkIII antibody, c-Crk antibody, Crk oncogene antibody, v-crk avian sarcoma virus CT10 oncogene homolog antibody, CRK proto-oncogene, adaptor protein antibody, v-crk avian sarcoma virus CT10 oncogene homolog L homeolog antibody, v-crk sarcoma virus CT10 oncogene homolog antibody, Crk antibody, crk antibody, CRK antibody, crk.L antibody
Background
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. Alias Symbols: p38, CRKII Protein Size: 304
Gene ID
1398
NCBI Accession
NM_005206 , NP_005197
UniProt
P46108
Pathways
Neurotrophin Signaling Pathway , CXCR4-mediated Signaling Events , Signaling of Hepatocyte Growth Factor Receptor
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