HMGCS2 antibody (Middle Region)

Catalog No. ABIN5516046

Product Details anti-HMGCS2 Antibody

Target: HMGCS2 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGCS2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ALDRCYTSYR KKIQNQWKQA GSDRPFTLDD LQYMIFHTPF CKMVQKSLAR

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HMGCS2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 29 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HMGCS2

Target: HMGCS2 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2))

Alternative Name: HMGCS2 (HMGCS2 Products)

Synonyms: 1300002P16 antibody, mHS antibody, DDBDRAFT_0219349 antibody, DDBDRAFT_0219924 antibody, DDB_0219349 antibody, DDB_0219924 antibody, Hmgcs1 antibody, Mt3h3mg antibody, hmgCoA antibody, 3-hydroxy-3-methylglutaryl-CoA synthase 2 antibody, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 antibody, hydroxymethylglutaryl-CoA synthase antibody, hydroxymethylglutaryl-coa synthase antibody, 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 antibody, HMGCS2 antibody, Hmgcs2 antibody, mvaS antibody, CNC05080 antibody, HMCS1 antibody, hgsA antibody, MFER_RS00425 antibody, LOC100285783 antibody, ECU10_0510 antibody, Eint_100450 antibody

Background: The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Protein Size: 466

Gene ID: 3158

NCBI Accession: NM_001166107, NP_001159579

Pathways: Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha