C77140 antibody, W91705 antibody, wu:fb81b10 antibody, zgc:101057 antibody, AU RNA binding methylglutaconyl-CoA hydratase antibody, AU RNA binding protein/enoyl-coenzyme A hydratase antibody, AU RNA binding protein/enoyl-CoA hydratase antibody, AU RNA binding protein/enoyl-CoA hydratase S homeolog antibody, AUH antibody, Auh antibody, auh antibody, auh.S antibody
Background
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92 % identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40- kDa precursor protein which is subsequently processed to a 32- kDa mature form.