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KIDINS220 antibody (Middle Region)
KIDINS220
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-KIDINS220 Antibody
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Target
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KIDINS220
(Kinase D-Interacting Substrate, 220kDa (KIDINS220))
Binding Specificity
All epitopes for KIDINS220 antibodies
Middle Region
Reactivity
All reactivities for KIDINS220 antibodies
Human
Host
All hosts for KIDINS220 antibodies
Rabbit
Clonality
All clonalities for KIDINS220 antibodies
Polyclonal
Conjugate
All conjugates for KIDINS220 antibodies
This KIDINS220 antibody is un-conjugated
Application
All applications for KIDINS220 antibodies
Western Blotting (WB)
Sequence
VERVPKSPEH SAEPIRTFIK AKEYLSDALL DKKDSSDSGV RSSESSPNHS
Predicted Reactivity
Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 100%, Zebrafish: 93%
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human KIDINS220
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for KIDINS220
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Target
KIDINS220
(Kinase D-Interacting Substrate, 220kDa (KIDINS220))
Alternative Name
KIDINS220 (KIDINS220 Products )
Synonyms
ARMS antibody, fj35h03 antibody, kidins220 antibody, zgc:63531 antibody, dZ119J18.2 antibody, wu:fj35h03 antibody, 3110039L19Rik antibody, AI194387 antibody, AI316525 antibody, C330002I19Rik antibody, mKIAA1250 antibody, kinase D interacting substrate 220 antibody, kinase D-interacting substrate 220 antibody, kinase D-interacting substrate 220b antibody, kinase D-interacting substrate 220kDa antibody, KIDINS220 antibody, Kidins220 antibody, kidins220b antibody
Background
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Alias Symbols: ARMS Protein Interaction Partner: UBC, LGR4, MYC, FN1, MOB4, CDC73, PRKD1, CRKL, NTRK2, NTRK3, NTRK1, NGFR, Protein Size: 59
Molecular Weight
543 kDa
Gene ID
57498
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