KRIT1 antibody (C-Term)

Catalog No. ABIN5516696

Product Details anti-KRIT1 Antibody

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KRIT1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LLQIVYGNYE SKKHKQGFLN EENLKSIVPV TKLKSKAPHW TNRILHEYKN

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KRIT1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KRIT1

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Alternative Name: KRIT1 (KRIT1 Products)

Synonyms: CAM antibody, CCM1 antibody, 2010007K12Rik antibody, A630036P20Rik antibody, AA432855 antibody, AI450393 antibody, AI643869 antibody, BB155247 antibody, BB235701 antibody, Ccm1 antibody, RGD1305929 antibody, krit1 antibody, fb36f07 antibody, san antibody, santa antibody, wu:fb36f07 antibody, zgc:63585 antibody, KRIT1, ankyrin repeat containing antibody, KRIT1 antibody, Krit1 antibody, krit1 antibody

Background: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Alias Symbols: CAM, CCM1

Protein Size: 529

Gene ID: 889

NCBI Accession: NM_001013406

Pathways: Cell RedoxHomeostasis