INPP5E antibody (Middle Region)

Catalog No. ABIN5516992

Product Details anti-INPP5E Antibody

Target: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INPP5E antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLQEIPKSRG VLSSERGSPS SGGNPLSGVA SSSPNLPHRD AAVAGSSPRL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human INPP5E

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for INPP5E

Target: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Alternative Name: INPP5E (INPP5E Products)

Synonyms: 1200002L24Rik antibody, 72kDa antibody, mKIAA0123 antibody, CORS1 antibody, CPD4 antibody, JBTS1 antibody, MORMS antibody, PPI5PIV antibody, PMPCA antibody, inositol polyphosphate-5-phosphatase E antibody, Inpp5e antibody, INPP5E antibody

Background: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome, a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: CPD4, CORS1, JBTS1, MORMS, PPI5PIV

Protein Size: 610

Gene ID: 56623

NCBI Accession: NM_019892, NP_063945