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KDM5B antibody (C-Term)
KDM5B
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-KDM5B Antibody
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Target
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KDM5B
(Lysine (K)-Specific Demethylase 5B (KDM5B))
Binding Specificity
All epitopes for KDM5B antibodies
C-Term
Reactivity
All reactivities for KDM5B antibodies
Human
Host
All hosts for KDM5B antibodies
Rabbit
Clonality
All clonalities for KDM5B antibodies
Polyclonal
Conjugate
All conjugates for KDM5B antibodies
This KDM5B antibody is un-conjugated
Application
All applications for KDM5B antibodies
Western Blotting (WB)
Sequence
EMKKFPDNDL LRHLRLVTQD AEKCASVAQQ LLNGKRQTRY RSGGGKSQNQ
Characteristics
This is a rabbit polyclonal antibody against KDM5B. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDM5B
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for KDM5B
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Target
KDM5B
(Lysine (K)-Specific Demethylase 5B (KDM5B))
Alternative Name
KDM5B (KDM5B Products )
Synonyms
jarid1b antibody, jarid1ba antibody, id:ibd5050 antibody, wu:fd15c05 antibody, cb264 antibody, jarid1bb antibody, plu1 antibody, wu:fc44h11 antibody, zgc:85741 antibody, JARID1B antibody, CT31 antibody, PLU-1 antibody, PLU1 antibody, PUT1 antibody, RBBP2H1A antibody, 2010009J12Rik antibody, 2210016I17Rik antibody, AW556288 antibody, D1Ertd202e antibody, Jarid1b antibody, Plu1 antibody, Rb-Bp2 antibody, mKIAA4034 antibody, RGD1565602 antibody, lysine (K)-specific demethylase 5Ba antibody, lysine (K)-specific demethylase 5Bb antibody, lysine demethylase 5B antibody, lysine (K)-specific demethylase 5B antibody, kdm5ba antibody, kdm5bb antibody, KDM5B antibody, Kdm5b antibody
Background
KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma. Alias Symbols: KDM5B, JARID1B, PLU1, RBBP2H1, Protein Interaction Partner: FBXW11, UBC, HDAC2, HDAC4, SUMO1, SUMO3, PPP1CA, TFAP2C, MYC, HDAC7, HDAC5, NCOR1, PAX9, HDAC1, ELAVL1, CHD3, MTA3, MBD3, KDM1A, MTA2, MBD2, RBBP7, RBBP4, RB1, SUMO2, KLF10, LMO2, FOXG1, AR, VGLL3, PRDM13, ARID1B, BMP2K, RNF43, RBM15B, DBNL, CECR6, SLC39A Protein Size: 1544
Gene ID
10765
NCBI Accession
NP_006609
UniProt
Q9UGL1
Pathways
Warburg Effect
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