RAD51 Homolog B antibody (Middle Region)

Catalog No. ABIN5517302

Product Details anti-RAD51 Homolog B Antibody

Target: RAD51 Homolog B (Rad51B)

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51 Homolog B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EFDAQLQGNL KERNKFLARE ASSLKYLAEE FSIPVILTNQ ITTHLSGALA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RAD51B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RAD51 Homolog B

Target: RAD51 Homolog B (Rad51B)

Alternative Name: RAD51B (Rad51B Products)

Synonyms: R51H2 antibody, RAD51L1 antibody, REC2 antibody, AI553500 antibody, Rad51l1 antibody, mREC2 antibody, ATRAD51B antibody, T17D12.12 antibody, T17D12_12 antibody, RGD1560681 antibody, rad51l1 antibody, wu:fd07f04 antibody, zgc:56581 antibody, RAD51 paralog B antibody, DNA repair (Rad51) family protein antibody, Rad51 DNA recombinase 2 antibody, RAD51B antibody, Rad51b antibody, rad51b antibody

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.

Alias Symbols: REC2, R51H2, RAD51L1

Protein Size: 279

Gene ID: 5890

NCBI Accession: NP_002868

Pathways: DNA Damage Repair