NKX2-1 antibody (N-Term)

Catalog No. ABIN5517366

Product Details anti-NKX2-1 Antibody

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NKX2-1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AVTAAYHMTA AGVPQLSHSA VGGYCNGNLG NMSELPPYQD TMRNSASGPG

Characteristics: This is a rabbit polyclonal antibody against NKX21. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen for Anti-NKX2-1 antibody is: synthetic peptide directed towards the N-terminal region of Human NKX21

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NKX2-1

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Alternative Name: NKX2-1 (NKX2-1 Products)

Synonyms: BCH antibody, BHC antibody, NK-2 antibody, NKX2.1 antibody, NKX2A antibody, TEBP antibody, TITF1 antibody, TTF-1 antibody, TTF1 antibody, titf1-A antibody, Xnkx-2.1 antibody, NKX2-1 antibody, LOC100227803 antibody, AV026640 antibody, Nkx2.1 antibody, T/EBP antibody, Titf1 antibody, Ttf-1 antibody, nk2.1a antibody, nkx2.1 antibody, nkx2.4a antibody, titf1 antibody, titf1a antibody, NK2 homeobox 1 antibody, NK2 homeobox 1 L homeolog antibody, NK2 homeobox 4b antibody, NKX2-1 antibody, nkx2-1.L antibody, Nkx2-1 antibody, nkx2.4b antibody

Background: This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.

Alias Symbols: BCH, BHC, NK-2, TEBP, TTF1, NKX2A, T/EBP, TITF1, TTF-1, NKX2.1

Protein Size: 371

Gene ID: 7080

NCBI Accession: NP_003308

UniProt: P43699

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour