FAM105B antibody (C-Term)

Catalog No. ABIN5517806

Product Details anti-FAM105B Antibody

Target: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM105B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NRAIELYNDK EKGKEVPFFS VLLFARDTSN DPGQLLRNHL NQVGHTGGLE

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against FAM105B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human FAM105B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FAM105B

Target: FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))

Alternative Name: FAM105B (FAM105B Products)

Synonyms: C79097 antibody, OTU deubiquitinase with linear linkage specificity antibody, OTULIN antibody, Otulin antibody

Background: FAM105B is a deubiquitinase that specifically removes linear ('M-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis. It associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. It is required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. FAM105B acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex

Alias Symbols: -

Protein Interaction Partner: FAM168A, DAZAP2, UBC, SHARPIN, RNF31, RBCK1, VCP, TNF, DVL2, DSTN, CUL4A, ELAVL1,

Protein Size: 352

Gene ID: 90268

NCBI Accession: NM_138348, NP_612357

UniProt: Q96BN8