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FAM105B antibody (C-Term)
FAM105B
Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FAM105B Antibody
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Target
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FAM105B
(Family with Sequence Similarity 105, Member B (FAM105B))
Binding Specificity
All epitopes for FAM105B antibodies
C-Term
Reactivity
Human, Mouse, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Rat
Host
All hosts for FAM105B antibodies
Rabbit
Clonality
All clonalities for FAM105B antibodies
Polyclonal
Conjugate
All conjugates for FAM105B antibodies
This FAM105B antibody is un-conjugated
Application
All applications for FAM105B antibodies
Western Blotting (WB)
Sequence
NRAIELYNDK EKGKEVPFFS VLLFARDTSN DPGQLLRNHL NQVGHTGGLE
Predicted Reactivity
Cow: 86%, Dog: 86%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 93%, Rat: 93%
Characteristics
This is a rabbit polyclonal antibody against FAM105B. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human FAM105B
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for FAM105B
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Target
FAM105B
(Family with Sequence Similarity 105, Member B (FAM105B))
Alternative Name
FAM105B (FAM105B Products )
Synonyms
C79097 antibody, OTU deubiquitinase with linear linkage specificity antibody, OTULIN antibody, Otulin antibody
Background
FAM105B is a deubiquitinase that specifically removes linear ('M-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis. It associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. It is required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. FAM105B acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex Alias Symbols: - Protein Interaction Partner: FAM168A, DAZAP2, UBC, SHARPIN, RNF31, RBCK1, VCP, TNF, DVL2, DSTN, CUL4A, ELAVL1, Protein Size: 352
Gene ID
90268
NCBI Accession
NM_138348 , NP_612357
UniProt
Q96BN8
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