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FAM105B antibody (C-Term)

FAM105B Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5517806
  • Target See all FAM105B products
    FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
    Binding Specificity
    • 7
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Rat
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    This FAM105B antibody is un-conjugated
    Application
    • 17
    • 16
    • 12
    • 12
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    NRAIELYNDK EKGKEVPFFS VLLFARDTSN DPGQLLRNHL NQVGHTGGLE
    Predicted Reactivity
    Cow: 86%, Dog: 86%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against FAM105B. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human FAM105B
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
    Alternative Name
    FAM105B (FAM105B Products)
    Synonyms
    C79097 antibody, OTU deubiquitinase with linear linkage specificity antibody, OTULIN antibody, Otulin antibody
    Background
    FAM105B is a deubiquitinase that specifically removes linear ('M-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis. It associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. It is required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. FAM105B acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex

    Alias Symbols: -

    Protein Interaction Partner: FAM168A, DAZAP2, UBC, SHARPIN, RNF31, RBCK1, VCP, TNF, DVL2, DSTN, CUL4A, ELAVL1,

    Protein Size: 352
    Gene ID
    90268
    NCBI Accession
    NM_138348, NP_612357
    UniProt
    Q96BN8
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