Myomesin 1 antibody (AA 904-933)

Catalog No. ABIN5533533

Product Details anti-Myomesin 1 Antibody

Target: Myomesin 1 (MYOM1)

Binding Specificity: AA 904-933

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Myomesin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MYOM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 904-933 amino acids from the Central region of human MYOM1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Myomesin 1

Target: Myomesin 1 (MYOM1)

Alternative Name: MYOM1 (MYOM1 Products)

Synonyms: SKELEMIN antibody, D430047A17Rik antibody, myomesin 1 antibody, myomesin 1, 185kDa antibody, MYOM1 antibody, Myom1 antibody

Background: The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50 % sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 188 kDa

Gene ID: 8736

UniProt: P52179