desert Hedgehog antibody (AA 195-223)

Catalog No. ABIN5534146

Product Details anti-desert Hedgehog Antibody

Target: desert Hedgehog (DHH) (Desert Hedgehog (DHH))

Binding Specificity: AA 195-223

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This desert Hedgehog antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for desert Hedgehog

Target: desert Hedgehog (DHH) (Desert Hedgehog (DHH))

Alternative Name: DHH (DHH Products)

Synonyms: GDXYM antibody, HHG-3 antibody, SRXY7 antibody, C78960 antibody, Xchh antibody, chh antibody, chh-a antibody, dhh antibody, dhh-1 antibody, dhh-A antibody, hh4 antibody, x-chh antibody, desert hedgehog antibody, desert hedgehog L homeolog antibody, desert hedgehog S homeolog antibody, DHH antibody, dhh antibody, Dhh antibody, dhh.L antibody, dhh.S antibody

Target Type: Species

Background: This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.

Molecular Weight: 44 kDa

Gene ID: 50846

UniProt: O43323

Pathways: Hedgehog Signaling