Nesprin3 antibody (C-Term)

Catalog No. ABIN5535388

Product Details anti-Nesprin3 Antibody

Target: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Binding Specificity: AA 852-880, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nesprin3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SYNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 852-880 amino acids from the C-terminal region of human SYNE3.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Nesprin3

Target: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Alternative Name: SYNE3 (C14orf49 Products)

Synonyms: C14orf49 antibody, NET53 antibody, Nesp3 antibody, 4831426I19Rik antibody, nesprin-3 antibody, spectrin repeat containing nuclear envelope family member 3 antibody, spectrin repeat containing, nuclear envelope family member 3 antibody, SYNE3 antibody, Syne3 antibody

Background: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.

Molecular Weight: 112 kDa

Gene ID: 161176

UniProt: Q6ZMZ3

Pathways: Maintenance of Protein Location