PSMD10 antibody (C-Term)

Catalog No. ABIN5536457

Product Details anti-PSMD10 Antibody

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Binding Specificity: AA 184-213, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD10 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSMD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-213 amino acids from the C-terminal region of human PSMD10.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PSMD10

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Alternative Name: PSMD10 (PSMD10 Products)

Synonyms: gankyrin antibody, zgc:109707 antibody, dJ889N15.2 antibody, p28 antibody, p28(GANK) antibody, AW554874 antibody, p28Gank antibody, proteasome 26S subunit, non-ATPase 10 antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 antibody, psmd10 antibody, PSMD10 antibody, Psmd10 antibody

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.

Molecular Weight: 24 kDa

Gene ID: 5716

UniProt: O75832

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway