GJA8 antibody (C-Term)

Catalog No. ABIN5536710

Product Details anti-GJA8 Antibody

Target: GJA8 (Gap Junction Protein, alpha 8, 50kDa (GJA8))

Binding Specificity: AA 402-433, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GJA8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-433 amino acids from the C-terminal region of human Connexin 50.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for GJA8

Target: GJA8 (Gap Junction Protein, alpha 8, 50kDa (GJA8))

Alternative Name: Connexin 50 (GJA8 Products)

Synonyms: Aey5 antibody, Cnx50 antibody, Cx50 antibody, Lop10 antibody, CAE antibody, CAE1 antibody, CTRCT1 antibody, CX50 antibody, CZP1 antibody, MP70 antibody, Cx45.6 antibody, gap junction protein, alpha 8 antibody, gap junction protein alpha 8 antibody, Gja8 antibody, GJA8 antibody

Background: GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.

Molecular Weight: 48 kDa

Gene ID: 2703

UniProt: P48165