UCP3 antibody (AA 1-113, AA 217-312)

Catalog No. ABIN5542343

Product Details anti-UCP3 Antibody

Target: UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

Binding Specificity: AA 1-113, AA 217-312

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This UCP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human UCP3 (AA: 1-113 and 217-312) expressed in E. coli.

Clone: 6B8C6

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: , ICC: 1:200 - 1:1000, FCM:

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for UCP3

Target: UCP3 (Uncoupling Protein 3 (Mitochondrial, Proton Carrier) (UCP3))

Alternative Name: UCP3 (UCP3 Products)

Synonyms: UCP antibody, UCP3 antibody, slc25a9 antibody, LOC100229080 antibody, SLC25A9 antibody, AI645527 antibody, Slc25a9 antibody, UCP-3 antibody, uncoupling protein 3 antibody, uncoupling protein antibody, mitochondrial uncoupling protein 3 antibody, uncoupling protein 3 (mitochondrial, proton carrier) S homeolog antibody, uncoupling protein 3 (mitochondrial, proton carrier) antibody, UCP3 antibody, UCP1 antibody, UCP2 antibody, LOC100303663 antibody, ucp3.S antibody, LOC100229080 antibody, Ucp3 antibody

Background:

Description: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression, this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.,

Aliases: SLC25A9

Molecular Weight: 34.2 kDa

Gene ID: 7352

HGNC: 7352

Pathways: Proton Transport