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Estrogen Receptor alpha antibody (AA 2-185)

The Mouse Monoclonal anti-Estrogen Receptor alpha antibody has been validated for WB, IHC, ELISA, FACS and ICC. It is suitable to detect Estrogen Receptor alpha in samples from Human and Rat.
Catalog No. ABIN5542593

Quick Overview for Estrogen Receptor alpha antibody (AA 2-185) (ABIN5542593)

Target

See all Estrogen Receptor alpha (ESR1) Antibodies
Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reactivity

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Human, Rat

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This Estrogen Receptor alpha antibody is un-conjugated

Application

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone

6A6E8
  • Binding Specificity

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    AA 2-185

    Purpose

    ESR1 Antibody

    Purification

    Purified antibody

    Immunogen

    Purified recombinant fragment of human ESR1 (AA: 2-185) expressed in E. Coli.

    Isotype

    IgG1
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target

    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

    Alternative Name

    ESR1

    Background

    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

    Molecular Weight

    66.2 kDa

    UniProt

    P03372

    Pathways

    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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