CX3CR1 antibody (3rd Extracellular Domain)

Catalog No. ABIN302578

Product Details anti-CX3CR1 Antibody

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Binding Specificity: 3rd Extracellular Domain

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CX3CR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antinody detects CX3C Chemokine Fractalkine Receptor 1 (CX3CR1) at 3rd extracellular domain.

Purification: Immunoaffinity chromatography

Immunogen: CX3CR1 antibody was raised against synthetic peptide from 3rd extracellular domain of human CX3CR1.

Application Details

Application Notes: Immunohistochemistry on paraffin sections (3.8 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for CX3CR1

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Alternative Name: CX3CR1 / GPR13 (CX3CR1 Products)

Synonyms: CCRL1 antibody, CMKBRL1 antibody, CMKDR1 antibody, GPR13 antibody, GPRV28 antibody, V28 antibody, Rbs11 antibody, C-X3-C motif chemokine receptor 1 antibody, chemokine (C-X3-C motif) receptor 1 antibody, CX3C chemokine receptor 1 antibody, CX3CR1 antibody, Cx3cr1 antibody, LOC100559882 antibody

Background: CX3CR1 a Chemokine Receptor is an HIV coreceptor, as well as a leukocyte chemotactic/adhesion receptor for fractalkine, also known as neurotactin. CX3CR1 mediates chemotactic responses to the soluble form of fractalkine in neutrophils and T cells, and cytoadhesion to cells expressing membrane-anchored fractalkine, such as monocytes, T cells, and neutrophils. Cells transfected with CX3CR1 exhibited chemotaxis and transient increases in intracellular calcium concentration when exposed to fractalkine.Synonyms: Beta chemokine receptor-like 1, C-X3-C CKR-1, CMK-BRL-1, CMKBRL1, CX3C chemokine receptor 1, Fractalkine receptor, G-protein coupled receptor 13, V28

Gene ID: 1524

NCBI Accession: NP_001164642

UniProt: P49238

Pathways: Cellular Response to Molecule of Bacterial Origin