MYRIP antibody (C-Term)

Catalog No. ABIN374340

Product Details anti-MYRIP Antibody

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This MYRIP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: C-KDLMEPALES AVMY

Specificity: This antibody detects MYRIP at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from C Terminus of the protein sequence according to NP_056275.2 Genename: MYRIP

Application Details

Application Notes: Peptide ELISA: Limit dilution 1/64000. Western blot: Use at 0.1-0.3 μg/mL. Approx 90 kDa band observed in Human Brain(Amygdala) lysates (Calculated MW of 95.0 kDa according to NP_056275.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris-saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.

Target Details for MYRIP

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Alternative Name: MYRIP (MYRIP Products)

Synonyms: SLAC2-C antibody, SLAC2C antibody, A230081N12Rik antibody, Slac2-c antibody, Slac2c antibody, MYRIP antibody, si:dkey-189e1.4 antibody, LOC100156583 antibody, myosin VIIA and Rab interacting protein antibody, MYRIP antibody, Myrip antibody, myrip antibody

Background: A molecular complex composed of Rab27A, MYRIP and myosin VIIa bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles. The defect of this molecular complex is likely to account for the perinuclear mislocalization of the melanosomes observed in the retinal pigment epithelium cells of myosin VIIa-defective mice.Synonyms: Exophilin-8, Myosin-VIIa- and Rab-interacting protein, Rab effector MyRIP, SLAC2C, SlaC2-c, Slp homolog lacking C2 domains c

Gene ID: 25924

NCBI Accession: NP_056275

UniProt: Q8NFW9

Pathways: Positive Regulation of Peptide Hormone Secretion