CCKAR antibody
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- Target See all CCKAR Antibodies
- CCKAR (Cholecystokinin A Receptor (CCKAR))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CCKAR antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- Reacts with Cholecystokinin A Receptor (CCKAR).
- Cross-Reactivity (Details)
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Species reactivity (expected):Monkey, Rat, Guinea pig.
Species reactivity (tested):Human. - Purification
- Immunoaffinity Chromatography.
- Immunogen
- CCKAR antibody was raised against synthetic peptide from human CCKAR. .Remarks: Mouse Identity: 45% Mouse Similarity: 55% Rat Identity: 80% Rat Similarity: 90%
- Isotype
- IgG
- Top Product
- Discover our top product CCKAR Primary Antibody
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- Application Notes
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Immunohistochemistry on Formalin Fixed Paraffin Embedded Tissues: 10 μg/mL (Requirespretreatment with Proteinase K).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.09 % Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.
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- Target
- CCKAR (Cholecystokinin A Receptor (CCKAR))
- Alternative Name
- CCK-A Receptor (CCKAR Products)
- Synonyms
- CCK-XL antibody, cck-a antibody, cck1-r antibody, cckar-A antibody, cckbr antibody, cckra antibody, CCKAR antibody, CCK-A antibody, CCK1-R antibody, CCKRA antibody, AW106902 antibody, Cck-ar antibody, CCK-AR antibody, cholecystokinin A receptor antibody, cholecystokinin A receptor L homeolog antibody, CCKAR antibody, cckar.L antibody, Cckar antibody
- Background
- The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.Synonyms: CCKA Receptor, CCKAR, CCKRA, Cholecystokinin receptor type A, Cholecystokinin-1 receptor
- Gene ID
- 886
- NCBI Accession
- NP_000721
- UniProt
- P32238
- Pathways
- Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Feeding Behaviour
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