Ankyrin G antibody

Catalog No. ABIN615371

Product Details anti-Ankyrin G Antibody

Target: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This Ankyrin G antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody recognizes Ankyrin 3, Node Of Ranvier (ankyrin G) (ANK3).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: ANK3 antibody was raised against synthetic peptide.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline buffer, pH ´7.3 containing 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Ankyrin G

Target: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Alternative Name: Ankyrin-3 (ANK3 Products)

Synonyms: ANK3 antibody, ankyrin-G antibody, 2900054D09Rik antibody, AI314020 antibody, Ank-3 antibody, AnkG antibody, Ankyrin-3 antibody, Ankyrin-G antibody, ANKYRIN-G antibody, ankyrin 3 antibody, ankyrin 3, node of Ranvier (ankyrin G) antibody, ankyrin 3, epithelial antibody, ANK3 antibody, legA6 antibody, PB000272.02.0 antibody, PY00018 antibody, ank3 antibody, Ank3 antibody

Background: Ankyrins are a family of spectrin-binding protein that couple the spectrin/actin cytoskeletal network to the cytoplasmic domains of integral membrane proteins which include channels such as the anion exchanger, voltage-dependent sodium channel and the Na/K ATPase. 3 forms of ankyrin G exists, 190 kDa, 270 kDa and 480 kDa, that are localized in the axonal intial segments and the nodes of Ranvier of myelinated axons where fluxes of action potential occur and ion channels are enriched.Synonyms: ANK-3, ANK3, Ankyrin G

Gene ID: 288

NCBI Accession: NP_066267

UniProt: Q12955

Pathways: Synaptic Membrane, Maintenance of Protein Location, Skeletal Muscle Fiber Development