ARTS antibody
Reactivity: Human
WB, IHC (p), EIA
Host: Rabbit
Polyclonal
unconjugated
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- Target
- ARTS
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificity
- ARTS antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human ARTS.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- Human ARTS Peptide
- Isotype
- IgG
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- Application Notes
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ELISA. Western Blot: ARTS antibody can be used for detection of ARTS at 0.5 to 2 μg/mL. Humanlung, kidney and spleen tissue lysates can be used as a positive control and a band at 32 kDa can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C.
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- Target
- ARTS
- Background
- Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
- Gene ID
- 5414
- UniProt
- Q9H315
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